The option "nohyper" causes the issue
\save_transient_properties true
\origin /systemlyxdir/examples/es/Handouts/
\textclass tufte-handout
-\use_default_options true
+\use_default_options false
\maintain_unincluded_children no
\language spanish
\language_package default
\output_sync 0
\bibtex_command bibtex
\index_command default
+\float_placement class
+\float_alignment class
\paperfontsize default
\spacing single
\use_hyperref false
\use_package stackrel 1
\use_package stmaryrd 1
\use_package undertilde 1
-\cite_engine basic
+\cite_engine natbib
\cite_engine_type default
\biblio_style plain
\use_bibtopic false
\suppress_date false
\justification true
\use_refstyle 0
+\use_formatted_ref 0
\use_minted 0
\use_lineno 0
\index Índice