The double-quotes are needed when there are two options.
Thanks to Jürgen.
\change_inserted -712698321 1644656496
\series bold
-PackageOptions hyperref option1,option
+PackageOptions hyperref
+\change_inserted 274215730 1652922468
+
+\begin_inset Quotes eld
+\end_inset
+
+
+\change_inserted -712698321 1644656496
+option1,option
\change_deleted 274215730 1652836969
1
-\change_inserted 274215730 1652836970
+\change_inserted 274215730 1652922466
2
+\begin_inset Quotes erd
+\end_inset
+
+
\change_unchanged
\end_layout
\begin_layout Quote
\series bold
-PackageOptions hyperref option1,option2
+PackageOptions hyperref
+\begin_inset Quotes eld
+\end_inset
+
+option1,option2
+\begin_inset Quotes erd
+\end_inset
+
+
\end_layout
\begin_layout Standard