The upcoming Mac OS version 10.11 (El Capitan) will not allow TeX the installation of links inside the /usr directory anymore.
# MISC SECTION ######################################
#
# MISC SECTION ######################################
#
-\path_prefix "/usr/texbin:/usr/local/gwTeX/bin/powerpc-apple-darwin-current:/usr/local/gwTeX/bin/i386-apple-darwin-current:/usr/local/teTeX/bin/powerpc-apple-darwin-current:/usr/local/teTeX/bin/i386-apple-darwin-current:/sw/bin:/sw/sbin:/opt/local/teTeX/bin:/opt/local/bin:/usr/local/bin:/usr/bin:/usr/X11R6/bin:/usr/sbin:/sbin"
+\path_prefix "/Library/TeX/texbin:/usr/texbin:/sw/bin:/sw/sbin:/opt/local/teTeX/bin:/opt/local/bin:/usr/local/bin:/usr/bin:/usr/X11R6/bin:/usr/sbin:/sbin"
\serverpipe "~/Library/Application Support/LyX@version_suffix@/.lyxpipe"
\preview on
\serverpipe "~/Library/Application Support/LyX@version_suffix@/.lyxpipe"
\preview on